With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348640-06-2,4-Bromo-7-azaindole,as a common compound, the synthetic route is as follows.
c.HNO3 (0.93 mL) was added drop wise to a solution of a H2SO4 (0.64 mL) at 0 C. 4-Bromo-1H-pyrrolo[2,3-b]pyridine (2 g, 10.15 mmol) in c.H2SO4 (9 mL) was added slowly, keeping the temperature at 0 C. After addition the reaction was stirred for a further hour at 0 C. before pouring carefully onto rapidly stirring ice/H2O (100 mL). The suspension was stirred for 30 mins and then the solids separated via filtration. The filter cake was washed with copious amounts of H2O before drying in vacuo at 40 C., to afford the desired compound, 1.9 g, 77.3%
348640-06-2, As the paragraph descriping shows that 348640-06-2 is playing an increasingly important role.
Reference£º
Patent; Vernalis (R&D) Limited; Stokes, Stephen; Graham, Christopher John; Ray, Stuart Christopher; Stefaniak, Emma Jane; US2015/11533; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles