With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35320-67-3,2-Methyl-1H-indol-4-ol,as a common compound, the synthetic route is as follows.
To a stirred solution of N-benzyl-2-chloro-5,6,7,8-tetrahydropyrido[2,3- d]pyrimidin-4-amine (150 mg, 0.548 mmol) in anhydrous dioxane (20 mL) were added 2-methyl-1H-indol-4-ol (80 mg, 0.55 mmol), Pd2(dba)3 (100 mg, 0.11 mmol), X-Phos (52 mg, 0.11 mmol) and Cs2CO3 (357 mg, 1.09 mmol). The reaction suspension was stirred at 100 oC for 2 hrs under N2. The inorganic salt and catalyst was removed via filtration. The filtrate was concentrated in vacuo. And the residue was purified via silica gel column (hexane/ethyl acetate) to afford 1-[4-(benzylamino)-5,6,7,8-tetrahydroquinazolin-2-yl]-2-methyl-indol-4- ol (120 mg, 51.3%) as yellow solid. LCMS (M+H+) m/z: Calcd: 385.20; Found: 385.2., 35320-67-3
As the paragraph descriping shows that 35320-67-3 is playing an increasingly important role.
Reference£º
Patent; CLEAVE BIOSCIENCES, INC.; ZHOU, Han-Jie; WUSTROW, David; (498 pag.)WO2016/200840; (2016); A1;,
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