387-44-0, 7-Fluoroindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,387-44-0
Example 37; 7-fluoro-1-f4-f4-fpyridin-2-yl)-1-fpyridin-3-yl)-1H-imidazol-2-yl)phenyl)-1H-indole; A mixture of 2-(2-(4-iodophenyl)-1-(pyridin-3-yl)-1H-imidazol-4-yl)pyridine (200 mg, 0.47 mmol), indole (76 mg, 0.56 mmol), CuI (134 mg, 0.7 mmol), K3PO4 (199 mg, 0.94 mmol) and fra?s-1,2-cyclohexanediamine (6 mg, 0.05 mmol) in p-dioxane (2 mL) was heated at 150 0C (bath) for 2h, filtered, concentrated, and the residue purified by SGC (0.5 and 1 % MeOH in DCM1 0.5 % NH4OH). Yield 80 mg, 39%. 1H NMR (CDCI3) delta 8.67 (m, 2H)1 8.57 (m, 1 H), 8.14 (d, 1H1 J = 7.9 Hz)1 7.93 (s, 1H), 7.77 (dt, 1H, J = 1.7, 7.7 Hz), 7.64 (m, 1H), 7.50 (m, 2H), 7.42-7.37 (m, 4H), 7.22-7.17 (m, 2H), 7.05 (m, 1H), 6.89 (dd, 1H1 J = 7.5, 13 Hz)1 6.68 (dd, 1H, J = 2.5, 3.3 Hz). MS (AP+) m/e 432 (MH+). IC50 = 30.8 ?M
387-44-0 7-Fluoroindole 2774504, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; PFIZER PRODUCTS INC.; WO2008/4117; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles