An article Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis WOS:000501529700127 published article about CANCER-CELLS; TETRANDRINE DERIVATIVES; BIOLOGICAL EVALUATION; ANTITUMOR AGENTS; IN-VITRO; DESIGN; METABOLISM; NQO1; VIVO in [Li, Sheng-You; Pan, Wei-Dong] Guizhou Univ, Coll Pharm, Huaxi Ave South, Guiyang 550025, Guizhou, Peoples R China; [Li, Sheng-You; Sun, Ze-Kun; Zeng, Xue-Yi; Zhang, Yue; Wang, Meng-Ling; Song, Jun-Rong; Chen, Chao; Luo, Heng; Pan, Wei-Dong] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China; [Sun, Ze-Kun] Guizhou Univ, Sch Med, Huaxi Ave South, Guiyang 550025, Guizhou, Peoples R China; [Zeng, Xue-Yi; Wang, Meng-Ling; Hu, Sheng-Cao; Song, Jun-Rong; Luo, Jun; Chen, Chao; Luo, Heng; Pan, Wei-Dong] Key Lab Chem Nat Prod Guizhou Prov, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China; [Zeng, Xue-Yi; Wang, Meng-Ling; Hu, Sheng-Cao; Song, Jun-Rong; Luo, Jun; Chen, Chao; Luo, Heng; Pan, Wei-Dong] Chinese Acad Sci, 3491 Baijin Rd, Guiyang 550014, Guizhou, Peoples R China; [Zhang, Yue] Guizhou Univ, Coll Agr, Huaxi Ave South, Guiyang 550025, Guizhou, Peoples R China in 2019.0, Cited 28.0. Computed Properties of C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
Twenty-seven L-shaped ortho-quinone analogs were designed and synthesized using a one pot double-radical synthetic strategy followed by removing methyl at C-3 of the furan ring and introducing a diverse side chain at C-2 of the furan ring. The synthetic derivatives were investigated for their cytotoxicity activities against human leukemia cells K562, prostate cancer cells PC3, and melanoma cells WM9. Compounds TB1, TB3, TB4, TB6, TC1, TC3, TC5, TC9, TC11, TC12, TC14, TC15, TC16, and TC17 exhibited a better broad-spectrum cytotoxicity on three cancer cells. TB7 and TC7 selectively displayed potent inhibitory activities on leukemia cells K562 and prostate cancer cells PC3, respectively. Further studies indicated that TB3, TC1, TC3, TC7, and TC17 could significantly induce the apoptosis of PC3 cells. TC1 and TC17 significantly induced apoptosis of K562 cells. TC1, TC11, and TC14 induced significant apoptosis of WM9 cells. The structure-activity relationships evaluation showed that removing methyl at C-3 of the furan ring and introducing diverse side chains at C-2 of the furan ring is an effective strategy for improving the anticancer activity of L-shaped ortho-quinone analogs.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles