4264-35-1, 1-(1H-Indol-2-yl)ethanone is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4264-35-1
5-Chloro-2-hydroxy-N’-((1E)-1-(1H-indol-2-yl)ethylidene)benzohydrazide (6t) To a mixture of methyl 5-chloro-2-hydroxybenzoate (162 mg, 0.87 mmol) in isobutanol (0.5 mL) was added hydrazine hydrate (42 muL, 0.87 mmol). The reaction mixture was irradiated with microwaves for 15 min at 115 C. Isobutanol was added and the supernatant was removed. The residue was taken up in isobutanol (0.5 mL) and 1-(1H-indol-2-yl)ethanone 3p (138 mg, 0.87 mmol) was added. The reaction mixture was again irradiated with microwaves for 10 min at 110 C. The solid product was filtered and then, triturated with EtOH and Et2O to afford 6t as a yellow solid (90 mg, 33%). Mp = 198-200 C. 1H NMR (400 MHz, DMSO-d6): delta 12.46 (s, 1H), 11.39 (s, 1H), 10.07 (s, 1H), 7.86 (d, J = 2.4 Hz, 1H), 7.60 (d, J = 7.6 Hz, 1H), 7.47 (d, J = 7.6 Hz, 1H), 7.41 (dd, J = 8.8 Hz, 2.4 Hz, 1H), 7.19 (tm, J = 7.6 Hz), 7.03 (m, 2H), 6.93 (d, J = 8.8 Hz, 1H), 2.48 (s, 3H). 13C NMR (100 MHz, DMSO-d6): delta 158.0, 153.8, 137.5, 136.5, 132.8, 127.7, 126.8, 123.4, 122.3, 120.9, 119.3, 119.1, 111.8, 104.9, 14.5. HRMS calcd for (C17H1435ClN3O2+Na)+ 350.0663, found 350.0667.
4264-35-1 1-(1H-Indol-2-yl)ethanone 589081, aindole-building-block compound, is more and more widely used in various fields.
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Article; Kumar, Nag S.; Amandoron, Emily A.; Cherkasov, Artem; Brett Finlay; Gong, Huansheng; Jackson, Linda; Kaur, Sukhbir; Lian, Tian; Moreau, Anne; Labriere, Christophe; Reiner, Neil E.; See, Raymond H.; Strynadka, Natalie C.; Thorson, Lisa; Wong, Edwin W.Y.; Worrall, Liam; Zoraghi, Roya; Young, Robert N.; Bioorganic and Medicinal Chemistry; vol. 20; 24; (2012); p. 7069 – 7082;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles