With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4771-48-6,4-Methyl-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.
The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (448 mg, 2 mmol) was dissolved in a solution of piperidine (0.1 mL) in toluene (6 mL), and 4-methyl-1H-indole-3-carboxaldehyde (156.8mg, 0.8mmol), reacted at 130 C for 4h,The organic phase was spin-dried, and the remaining crude product was recrystallized from ethanol to obtain the target compound (E)-2-methyl-3-(4-methyl-1H-indol-3-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (1) 230mg,The yield was 51.3%.
4771-48-6, 4771-48-6 4-Methyl-1H-indole-3-carbaldehyde 2762437, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
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