5192-03-0, 1H-Indol-5-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of lH-indol-5 -amine (0.6 g, 4.54 mmol) in dichloromethane (15 mL), was added triethylamine (1.3 mL, 9.08 mmol) and a solution of tert butyl carbonyl chloride (0.46 mL, 5.44 mmol) in dichloromethane (2 mL) at 0C and stirred for 1.5 h. The reaction mixture was diluted with dichloromethane and washed with water, and the organic phase was dried over anhydrous Na2S04 and concentrated in vacuo. The resultant residue was purified and yielded N-(lH-indol-5-yl)pivalamide (0.88 g, 89%). MS: 217 (M+1); 1H NMR (400 MHz, DMSO-d6) delta; 1.22 (s, 9H), 6.34-6.35 (m, 1H), 7.20 (dd, J = 8.8, 2.0 Hz, 1H), 7.26-7.29 (m, 2H), 7.77 (d, J= 2.0 Hz, 1H), 9.00 (s, 1H), 10.96 (s, 1H).
5192-03-0, 5192-03-0 1H-Indol-5-amine 78867, aindole-building-block compound, is more and more widely used in various fields.
Reference：
Patent; LUPIN LIMITED; THOTAPALLY, Rajesh; PATHAK, Ashok, Bhau; KARDILE, Bhavana, Shrirang; SINDKHEDKAR, Milind, Dattatraya; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2012/25811; (2012); A1;,
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