6127-17-9, 6-Chloro-2-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6127-17-9, Example 6Synthesis of CBX0044-(2-(6-chloro-2-methyl-lH-indol-l-yl)ethyl)morpholine[0161] To a solution of 2-chloroethylmorpholine HC1 (134 mg, 0.72 mmol) in 0.3 mL DMSO was added pulverized KOH (102 mg, 1.81 mmol), then after 10 min, a solution of 6- chloro-2-methylindole (100 mg, 0.60 mmol) in 0.2 mL DMSO was added and the reaction stirred at room temperature overnight. Additional 2-chloroethylmorpholine (22 mg, 0.12 mmol) and KOH (17 mg, 0.3 mmol) added and stirred overnight. The reaction mixture was partitioned between ?0 and toluene, and the organic extract washed two times with ?0, dried over MgS04, filtered, and concentrated in vacuo. The crude product was purified via silica gel chromatography using a gradient from 0 to 50% ethyl acetate in hexane to give a final yield of 149 mg (0.54 mmol). XH NMR (500 MHz, CDC13, delta): 2.44 (s, 3H), 2.49 (t, J = 4.4 Hz, 4H), 2.62 (t, J = 7.2 Hz, 2H), 3.73 (t, J = 4.5 Hz, 4H), 4.11 (t, J= 7.2 Hz, 2H), 6.23 (s, 1H), 7.06 (dd, J = 8.4 Hz, 1.7 Hz, 1H), 7.28 (s, 1H), 7.42 (d, J = 8.3 Hz, 1H). 13C NMR (500 MHz, CDC13, delta): 12.79, 41.18, 54.11, 57.83, 67.5, 100.30, 108.95, 119.90, 120.53, 126.40, 126.70, 137.06, 137.37. MS m/z 279.3 [M + H]+.
The synthetic route of 6127-17-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION; STELLA, Nephi; KLINE, Toni; WO2012/24670; (2012); A2;,
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