With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6146-52-7,5-Nitroindole,as a common compound, the synthetic route is as follows.,6146-52-7
KOH (5 eq.) was added to asolution of indole (1 eq.) dissolved in acetone (5 mL/mmol ofindole) at 0 C. Iodomethane (2 eq.)was added. Solutionwas stirredat 40 C until disappearance of indole by TLC. Reaction was thencooled to room temperature. DCM (33 mL/mmol of indole) wasadded to reaction and stirred for 30 min. The solid was then filteredout and filtrate was washed 2 H2O, 1 1M HCl, and 2 H2O.Organic layer was dried with Mg2SO4 and rotovapped. Crudeproduct was recrystallized. Yellow solid; 65e100%; 1H NMR(CDCl3): d8.61 (m, 1H), 8.16 (dd, 1H), 7.36 (dt, 1H), 7.23 (d, 1H), 6.70(dd, 1H), 3.89 (s, 3H); 13C NMR (CDCl3): d139.43, 132.00, 127.63,118.18, 117.27, 109.08, 103.86, 99.99, 33.32.
The synthetic route of 6146-52-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Martinez, Anastasia A.; Espinosa, Bianca A.; Adamek, Rebecca N.; Thomas, Brent A.; Chau, Jennifer; Gonzalez, Edwardo; Keppetipola, Niroshika; Salzameda, Nicholas T.; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 1202 – 1213;,
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