6960-46-9,6960-46-9, Ethyl 7-nitro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 3: Preparation of Compound 3 (7-Nitro-1H-indole-2-carboxylic acid); The compound 2 (13.79 g, 58.88 mmol) was added into a flask (250 mL), ethanol (72.7 mL, 40 C) was added into the flask, and the solution was stirred for 5 min. Then, a solution of KOH formulated with KOH (7.25 g, 189.59 mmol) and water (17.40 g) was added into the solution, and the solution was stirred for 5 min to obtain a clear solution with red oxide color. When the solution was cooled down, a yellow-brown solid was started to precipitate. After the solution was stirred for 3 hr, hot water (295 mL) was added to dissolve the yellow-brown solids to obtain a clear solution with red oxide color. Then, 3 N of HCl was added into the solution, and a breast-yellow solid was precipitated. The solution was kept stirring unitl the precipitation of the yellow solids was stopped, and filtered. The yellow solids were washed by water, dried, and re-crystallized in ethanol to obtain a fiber-shaped light-yellow solid, compound 3 (11.57 g, 96%). mp 269-271 C (lit. 269-272 C); 1H NMR (200 MHz, DMSO-d6) delta7.35 (t, J= 8.0 Hz, 1H, ArH), 7.40 (d, J= 2.0 Hz, 1H, ArH), 8.22 (d, J= 7.8 Hz, 1H, ArH), 8.27 (dd, J= 0.8, 8.0 Hz, 1H, ArH), 11.16 (s, 1H, NH); 13C NMR (50 MHz, acetone-d6) delta109.6, 110.0, 120.6, 122.3, 130.1, 131.3, 131. 8, 134.0, 161.6; MS (EI) m/z 206 (M+, 100%), 188 (M-18, 65%), 142 (M-64, 49%), 114 (M-92, 43%).
The synthetic route of 6960-46-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Purzer Pharmaceutical Co., Ltd.; EP2366687; (2011); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles