933-67-5, 7-Methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Trifluoromethyl ketone (0.3mmol),trifluoromethanesulfonicacid (9mg, 0.06mmol) were added to a dry sealed tube charged with indole(0.9mmol) and sodium sulphate anhydrous (12.8mg, 0.09mmol) under argon. Thereaction mixture was stirred at 115C for 12h. After the reaction was completed, the mixture was purifiedby column chromatography on silica gel with hexanes/ethyl acetate as eluent.The desired product was obtained as white or pale yellow solid. Isolated yield: 82%. White solid. M.P.: 116-120oC.1H NMR (400 MHz, CDCl3) delta 8.10 (s, 2 H), 7.44 (d, J= 2.0 Hz, 2 H), 6.82 (d, J = 6.8 Hz, 2 H), 6.68-6.60 (m, 4 H), 2.46(s, 6 H), 2.02-1.95 (m, 1 H), 0.59-0.54 (m, 2 H), 0.29-0.25 (m, 2 H); 19FNMR (375 MHz, CDCl3) delta -69.53 (s, 3 F); 13C NMR(100.7 MHz, CDCl3) delta 135.6, 128.6 (q, J = 284.8 Hz), 126.7,124.3 (q, J = 2.2 Hz), 122.1, 119.8, 119.4, 119.3, 50.4 (q, J = 26.0Hz), 16.5, 15.4 (q, J = 2.2 Hz), 2.2 ppm. IR (KBr): nu = 3415, 3050,3012, 2959, 2922, 2855, 1615, 1541, 1495, 1457, 1431, 1409, 1380, 1345, 1319,1251, 1185, 1147, 1123, 1098, 1068, 1028, 1017, 994, 960, 924, 883, 844, 817,782, 750, 723, 581, 516, 483, 458 cm-1. MS (EI): m/z (%) 382(M , 100), 354, 313, 251,157, 144, 57. HRMS: Calculated for C23H21F3N2: 382.1657; Found: 382.1652
The synthetic route of 933-67-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wang, Yi; Yuan; Xing, Chun-Hui; Lu, Long; Tetrahedron Letters; vol. 55; 5; (2014); p. 1045 – 1048;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles