938465-52-2, 1-Chloro-5H-pyrido[4,3-b]indole-4-carboxamide is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,938465-52-2
To the mixture of Intermediate 1(1 g, 4.07 mmol) in 30 mL of CF3COOH was added NIS (0.916 g, 4.07 mmol), then the mixture was stirred at room temperature overnight.Water (200 mL) was added into the mixture after it was cooled to room temperature, which wasfiltered and washed with water to yield 1 -chloro-8-iodo-5H-pyrido[4,3 -bj indole-4-carboxamide,which was used in the next step without further purification. ?HNMR(300MHz, DMSO-d6)oe12.33 (s, 1 H), 8.67 (s, 1 H), 8.61 (s,1 H), 8.37 (s, 1 H), 7.83 (d, J=8.4 Hz, 1 H), 7.61 (d, J=8.4Hz, 1 H) ppm.
The synthetic route of 938465-52-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph; KIM, Ronald; GAO, Xiaolei; BOGA, Sobhana Babu; YU, Younong; WU, Hao; LIU, Shilan; YANG, Chundao; (102 pag.)WO2016/164284; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles