Recommanded Product: 100-51-6. Authors Hua, YB; Wang, ZM; Wang, D; Lin, XM; Liu, BS; Zhang, H; Gao, J; Zheng, AP in MDPI published article about in [Hua, Yabing; Wang, Zengming; Wang, Dan; Lin, Xiaoming; Liu, Boshi; Zhang, Hui; Gao, Jing; Zheng, Aiping] Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, 27th Taiping Rd, Beijing 100850, Peoples R China in 2021.0, Cited 37.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
The FDA (U.S. Food and Drug Administration) has approved only a negligible number of poly(lactide-co-glycolide) (PLGA)-based microsphere formulations, indicating the difficulty in developing a PLGA microsphere. A thorough understanding of microsphere formulations is essential to meet the challenge of developing innovative or generic microspheres. In this study, the key factors, especially the key process factors of the marketed PLGA microspheres, were revealed for the first time via a reverse engineering study on Vivitrol(R) and verified by the development of a generic naltrexone-loaded microsphere (GNM). Qualitative and quantitative similarity with Vivitrol(R), in terms of inactive ingredients, was accomplished by the determination of PLGA. Physicochemical characterization of Vivitrol(R) helped to identify the critical process parameters in each manufacturing step. After being prepared according to the process parameters revealed by reverse engineering, the GNM demonstrated similarity to Vivitrol(R) in terms of quality attributes and in vitro release (f(2) = 65.3). The research on the development of bioequivalent microspheres based on the similar technology of Vivitrol(R) will benefit the development of other generic or innovative microspheres.
Recommanded Product: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Hua, YB; Wang, ZM; Wang, D; Lin, XM; Liu, BS; Zhang, H; Gao, J; Zheng, AP or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles