Sequentially Catalyzed Three-Component Masuda-Suzuki-Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion was written by Driessen, Daniel;Biesen, Lukas;Mueller, Thomas J. J.. And the article was included in Synlett in 2021.Name: 1H-Pyrrolo[2,3-b]pyridine This article mentions the following:
The Masuda-Suzuki-Sonogashira sequence efficiently united in a one-pot fashion, a borylation, an arylation and an alkynylation in the sense of a sequentially Pd-catalyzed three-component reaction to give fluorescent 2-alkynyl-4-(7-azaindol-3-yl)pyrimidines in yields of 24-83%. Time-dependent d.-functional theory calculations supported the electronic structure of the longest wavelength absorption bands, and revealed that this novel consecutive three-component synthesis opened an efficient access to alkynyl meriolins, a novel class of potential inducers of apoptosis. In the experiment, the researchers used many compounds, for example, 1H-Pyrrolo[2,3-b]pyridine (cas: 271-63-6Name: 1H-Pyrrolo[2,3-b]pyridine).
1H-Pyrrolo[2,3-b]pyridine (cas: 271-63-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 1H-Pyrrolo[2,3-b]pyridine
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles