Synthesis of 1-indolyl-3,5,8-substituted 纬-carbolines: one-pot solvent-free protocol and biological evaluation was written by Dudhe, Premansh;Krishnan, Mena Asha;Yadav, Kratika;Roy, Diptendu;Venkatasubbaiah, Krishnan;Pathak, Biswarup;Chelvam, Venkatesh. And the article was included in Beilstein Journal of Organic Chemistry in 2021.HPLC of Formula: 27421-51-8 This article mentions the following:
1,5-Disubstituted indole-2-carboxaldehyde derivatives and glycine alkyl esters underwent a novel cascade imination-heterocylization in the presence of the organic base DIPEA to provide 1-indolyl-3,5,8-substituted 纬-carbolines I [R1 = H, MeO, Ph; R2 = Me, benzyl, tosyl, etc.; R3 = MeOOC, EtOOC, t-BuOOC] and II in good yields. The 纬-carbolines I and II are fluorescent and exhibited anticancer activities against cervical, lung, breast, skin and kidney cancer cells. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8HPLC of Formula: 27421-51-8).
1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.HPLC of Formula: 27421-51-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles