On June 6, 2002, Dugar, Sundeep; Mavunkel, Babu J.; Luedtke, Gregory R.; Mcenroe, Glen published a patent.Formula: C9H6ClNO2 The title of the patent was Preparation of indolecarboxamides as p38-α inhibitors. And the patent contained the following:
Title compounds were prepared as p38-α inhibitors (no data). Thus, 6-chloro-1-methyl-1H-indole-5-carboxylic acid was amidated by (R)-3-aminomethyl-1-benzylpyrrolidine followed by acylation and amidation to give title compound I. The experimental process involved the reaction of 6-Chloro-1H-indole-5-carboxylic acid(cas: 256935-86-1).Formula: C9H6ClNO2
The Article related to indolecarboxamide preparation p38alpha inhibitor, antiinflammatory indolecarboxamide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C9H6ClNO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles