Asymmetric sulfenylation of 3-CF3-Oxindoles through organocatalysis with a quinidine derivative was written by E, Yidan;Yuan, Teng;Yin, Liang;Xu, Youjun. And the article was included in Tetrahedron Letters in 2017.Synthetic Route of C14H9NO2S This article mentions the following:
An asym. sulfenylation of 3-CF3-oxindoles catalyzed by a quinidine derivative was described. 3-CF3-oxindoles with electro-donating groups led to corresponding products in good yield and with good enantioselectivity while 3-CF3-oxindoles bearing electro-withdrawing groups were not competent substrates due to its significant decomposition at the optimal reaction conditions. As for the sulfenylation reagents based on thiophenol, both electro-donating groups and electro-withdrawing groups were well tolerated. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Synthetic Route of C14H9NO2S).
2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Synthetic Route of C14H9NO2S
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles