Elkin, Samuel published the artcileSynthesis and local anesthetic activity of several dialkylaminoalkyl esters of indolecarboxylic acids, Category: indole-building-block, the publication is Journal of Pharmaceutical Sciences (1963), 79-81, database is CAplus.
By the method of Burtner and Cusic (CA 37, 17113), compounds having the general formulas I and II were prepared (compound, R, n, % yield, and m.p. given): I, H, 2, 25, 174-5°; I, H, 3, 21.8, 165-7°; I, NO2, 2, 15.6, 210-12°; I, NO2, 3, 15.1, 208-10°; II, –, 2, 6.2, 178-80°; II, –, 3, 17.5, 170-1°. All compounds were effective as topical anesthetics but had no action on unbroken skin. Nitrated indole-3-carboxylic acid and the esters of indole-2-carboxylic acid showed a marked decrease in duration of local anesthetic activity.
Journal of Pharmaceutical Sciences published new progress about 10242-03-2. 10242-03-2 belongs to indole-building-block, auxiliary class Indole,Nitro Compound,Carboxylic acid,Indole, name is 6-Nitro-1H-indole-3-carboxylic acid, and the molecular formula is C9H6N2O4, Category: indole-building-block.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles