Eskola, Olli published the artcileSynthesis of 3-[[4-(4-[18F]fluorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine, Quality Control of 5654-92-2, the main research area is fluorophenylpiperazinylmethylpyrrolopyridine preparation biodistribution.
3-[[4-(4-[18F]fluorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine, a candidate to image dopamine D4 receptors, was synthesized via electrophilic fluorination of a trimethylstannyl precursor with high specific radioactivity [18F]F2. The precursor was obtained by a facile four-step synthetic approach; the trimethylstannyl leaving group was introduced by displacement of iodine utilizing palladium catalysis and hexamethyldistannane in an inert solvent. The total radiosynthesis time was 50 min, including purification and formulation for injection. Decay corrected radiochem. yield was <1% as calculated from the amount of [18F]F- produced. Specific radioactivity at the end of synthesis was 12.8-16.4 GBq/μmol. Radiochem. purity was 88-92%. Ex vivo studies in rats showed homogeneous distribution of radioactivity within rat brain. Journal of Labelled Compounds & Radiopharmaceuticals published new progress about fluorophenylpiperazinylmethylpyrrolopyridine preparation biodistribution. 5654-92-2 belongs to class indole-building-block, name is N,N-Dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanamine, and the molecular formula is C10H13N3, Quality Control of 5654-92-2.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles