Kamochi, Yasuko;Watanabe, Yasuo published 《Synthesis of isoindolinones by the amidomethylation of N-(hydroxymethyl)benzamides with pyrophosphoric acid》 in 1989. The article was appeared in 《Daiichi Yakka Daigaku Kenkyu Nenpo》. They have made some progress in their research.Related Products of 132680-54-7 The article mentions the following:
Synthesis of 1-isoindolinones by amidomethylation of N-(hydroxymethyl)benzamides with an electron-donating group para to the ring-closure site with pyrophosphoric acid is described, and a conversion of some amidomethylated intermediates into 1-isoindolinones is discussed. The experimental procedure involved many compounds, such as 6-Methoxyisoindolin-1-one (cas: 132680-54-7) .
The crystal structure of 6-Methoxyisoindolin-1-one(cas:132680-54-7 Related Products of 132680-54-7) has been determined using x-ray crystallography and cell studies. It was found that 6-Methoxyisoindolin-1-one inhibits the interactions of chk1 with substructures of DNA, such as the major groove and minor groove.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles