Lopez-Valdez, German;Olguin-Uribe, Simon;Millan-Ortiz, Alejandra;Gamez-Montano, Rocio;Miranda, Luis D. published 《Convenient access to isoindolinones via carbamoyl radical cyclization: Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products》 in 2011. The article was appeared in 《Tetrahedron》. They have made some progress in their research.Quality Control of 6-Methoxyisoindolin-1-one The article mentions the following:
An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Addnl., the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization. And 6-Methoxyisoindolin-1-one (cas: 132680-54-7) was used in the research process.
6-Methoxyisoindolin-1-one(cas:132680-54-7 Quality Control of 6-Methoxyisoindolin-1-one) is a class III topoisomerase inhibitor that binds to the chk1 protein, which is an enzyme involved in DNA replication. 6-Methoxyisoindolin-1-one inhibits the interaction between the chk1 protein and DNA, preventing DNA replication.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles