In 2020.0 XENOBIOTICA published article about HUMAN ARYLACETAMIDE DEACETYLASE; HUMAN CARBOXYLESTERASE; ESTER; IDENTIFICATION; PARAOXONASES; PURIFICATION; HYDROLYSIS; SUBSTRATE; CLONING; ENZYME in [Mizoi, Kenta; Takahashi, Masato; Sakai, Sachiko; Haba, Masami; Hosokawa, Masakiyo] Chiba Inst Sci, Fac Pharm, 15-8 Shi Cho, Choshi, Chiba 2880025, Japan; [Mizoi, Kenta; Ogihara, Takuo] Takasaki Univ Hlth & Welf, Fac Pharm, Takasaki, Gumma, Japan in 2020.0, Cited 28.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. SDS of cas: 100-51-6
1. We investigated the structure-activity relationship of 31 kinds of synthesized atorvastatin esters, thioesters, amides and lactone, selected as prodrug models, for metabolic activation by microsomes and hydrolases. 2. The susceptibility to human carboxylesterase 1 (hCES1) was influenced not only by the size of the acyl group and alkoxy group but also by the degree of steric crowding around the alkoxy group. 3. The susceptibility to human carboxylesterase 2 (hCES2) increased with a decrease in electron density around the alkoxy group of the substrate. 4. Lactone was specifically hydrolyzed by paraoxonase 3 (PON3). 5. These findings should be useful in prodrug design for controlling metabolic activation.
About Benzyl Alcohol, If you have any questions, you can contact Mizoi, K; Takahashi, M; Sakai, S; Ogihara, T; Haba, M; Hosokawa, M or concate me.. SDS of cas: 100-51-6
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles