Extended knowledge of 1008-89-5

Although many compounds look similar to this compound(1008-89-5)Recommanded Product: 1008-89-5, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Dayanidhi, P. David; Vaidyanathan, V. G. published an article about the compound: 2-Phenylpyridine( cas:1008-89-5,SMILESS:C1(C2=CC=CC=C2)=NC=CC=C1 ).Recommanded Product: 1008-89-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1008-89-5) through the article.

Mutagenic agents such as aromatic amines undergo metabolic activation and produce DNA adducts at C8 position of guanine bases. N-2-acetylaminofluorene (AAF) generates different mutational outcomes when placed at G1, G2, and G3 of a NarI sequence (-G1G2CG3CC/T-). These outcomes are dictated by the conformations adopted by these adducts. Detection of such lesions is of considerable interest owing to their hazardous effects. Here, we report the synthesis of three cyclometalated [Ir(L)2dppz]+ complexes (L = 2-phenylpyridine (ppy) 1; benzo[h]quinoline (bhq) 2; 2-phenylquinoline (pq) 3; dppz = dipyrido[3,2-a:2,3-c]phenazine) and their interaction with AAF adducted NarI DNA. Remarkably, complexes 1 and 2 displayed dominant 3LC transition characteristic of polar environment despite binding to the adducted sites. On the other hand, complex 3 binds to NarI sequences and behaves as a luminescent reporter for AAF-modified DNA. The results reported here emphasize that mol. light switching phenomenon can be stimulated by switching ancillary ligands and might act as potential probes for covalent-DNA defects.

Although many compounds look similar to this compound(1008-89-5)Recommanded Product: 1008-89-5, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles