Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.119-36-8, Name is Methyl Salicylate, SMILES is COC(=O)C1=C(O)C=CC=C1, belongs to indole-building-block compound. In a document, author is Deng, Xiong-fei, introduce the new discover, Quality Control of Methyl Salicylate.
Hydroxyl alkylation of indoles by Friedel-Crafts reaction with a carbonyl compound is a useful strategy. However, the reaction was restricted to ketones due to the easy formation of a bisindole byproduct. Therefore, hydroxyl alkylation of an aldehyde with indole is confronted with great challenges. Here, we report an efficient strategy for asymmetric hydroxyl alkylation of 2-substituted indoles with aldehydes under 0.1 mol% chiral phosphoric acid. A series of alpha-hydroxyl ketones were obtained in high yields (up to 99%) and good enantioselectivities (up to 97%).
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 119-36-8 is helpful to your research. Quality Control of Methyl Salicylate.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles