Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 1218-69-5, Name is 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one, molecular formula is , belongs to indole-building-block compound. In a document, author is Karthikeyan, Subramani, Application In Synthesis of 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one.
Understanding the Binding Mechanism of a Pyrazino[1,2-a]indole Derivative with Calf Thymus DNA
This work was focused on understanding the interaction mechanism of pyrazino[1,2-a]indole derivative in calf thymus DNA (ctDNA) using various spectroscopy and computational techniques. The UV-Vis absorption result shows that the binding interaction of pyrazino[1,2-a]indole derivative in ctDNA complex may be in the non -covalent form and the binding associate constant K-a value was estimated 7.06×10(3)Lmol(-1) at 297K. The fluorescence emission spectroscopy analysis suggested that pyrazino[1,2-a]indole derivative quenching mechanism in ctDNA mainly due to the static nature and thermodynamical parameter analysis implied the binding of pyrazino[1,2-a]indole derivative in ctDNA mainly due to hydrophobic force. Forster resonance energy transfer analysis was also calculated and the r=2.1nm. Circular dichroism spectra conclude that there is a change in the secondary structural region of ctDNA due to an interaction with pyrazino[1,2-a]indole derivative. Together with the molecular docking studies, hydrophobic nature of the interaction of pyrazino[1,2-a]indole derivative with ctDNA might be deduced.
If you are hungry for even more, make sure to check my other article about 1218-69-5, Application In Synthesis of 2-(2-Hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles