Speri, E; Kim, C; De Benedetti, S; Qian, YY; Lastochkin, E; Fishovitz, J; Fisher, JF; Mobashery, S in [Speri, Enrico; Kim, Choon; De Benedetti, Stefania; Qian, Yuanyuan; Lastochkin, Elena; Fishovitz, Jennifer; Fisher, Jed F.; Mobashery, Shahriar] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA published Cinnamonitrile Adjuvants Restore Susceptibility to beta-Lactams against Methicillin-Resistant Staphylococcus aureus in 2019, Cited 49. Application In Synthesis of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.
beta-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. aureus (MRSA) renders them clinically precarious. We describe a class of cinnamonitrile adjuvants that restore the activity of oxacillin (a penicillin member of the beta-lactams) against MRSA. The lead adjuvants were tested against six important strains of MRSA, one vancomycin-intermediate S. aureus (VISA) strain, and one linezolid-resistant S. aureus strain. Five compounds out of 84 total compounds showed broad potentiation. At 8 mu M (E)-3-(5-(3,4-dichlorobenzy1)-2-(trifluoromethoxy)phenyl)-2-(methylsulfonyl)acrylonitrile (26) potentiated oxacillin with a >4000-fold reduction of its MIC (from 256 to 0.06 mg.L-1). This class of adjuvants holds promise for reversal of the resistance phenotype of MRSA.
Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Speri, E; Kim, C; De Benedetti, S; Qian, YY; Lastochkin, E; Fishovitz, J; Fisher, JF; Mobashery, S or concate me.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles