Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of Retinoic acid302-79-4, Name is Retinoic acid, SMILES is CC1(C(=C(CCC1)C)C=CC(=CC=CC(=CC(O)=O)C)C)C, belongs to indole-building-block compound. In a article, author is Pi, Chao, introduce new discover of the category.
Directed C3-Alkoxymethylation of Indole via Three-Component Cascade Reaction
An efficient and regioselective C3-alkoxymethylation of indoles has been developed with aldehydes and alcohols via three-component cascade reaction under transition-metal free conditions. This method allows for rapid access to a variety of C3-alkoxymethylaed free (N-H) indole in up to 98% yield with excellent regioselectivity. The titled products are useful building blocks in organic synthesis.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 302-79-4. Quality Control of Retinoic acid.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles