Recently I am researching about PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY; GRAPHENE QUANTUM DOTS; CANDIDA-ALBICANS; THERAPY; INACTIVATION; SUBSTITUENTS; CULTURES; BINDING; DESIGN; HYBRID, Saw an article supported by the Department of Science and Innovation (DSTI), South Africa through DSI/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]; National Research Foundation (NRF) , South Africa through DSI/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]; Rhodes University; Organization for Women in Science for the Developing World (OWSD); Swedish International Development Cooperation Agency (Sida). SDS of cas: 99-93-4. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Openda, YI; Nyokong, T. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
Photodynamic antimicrobial therapy (PACT) is a powerful technic recommended to eliminate life-threatening pathogens that cause localized and superficial infections as pathogens cannot develop resistance to it. For this reason, new positively charged chalcone substituted zinc (3a) and indium (4a) metalated phthalocyanines (Pcs) were synthesized and were pi-pi interacted with detonation nanodiamonds (DNDs) nanoparticles to form new water soluble nanoplatfoms 3a@DNDs and 4a@DNDs. The conjugates generated high singlet oxygen quantum yields (Phi(Delta)) in water (1% DMSO, used for PACT studies) with values of 0.46 and 0.47 for 3a@DNDs and 4a@DNDs, respectively. Hence, they were tested for PACT against biofilms of S. aureus and E. coli, as well as their planktonic cells. The quaternized Pcs alone 3a and 4a as well as their nanoconjugates 3a@DNDs and 4a@DNDs were effective PACT agents with log(10) CFU > 9 for E. coli and S. aureus. The quaternized derivatives were found to have higher ability to completely suppress both planktonic and biofilms of S. aureus and E. coli in vitro. Therefore, they could be used as appropriate photosensitive agents.
SDS of cas: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles