Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Yang, Yanli, once mentioned the application of 571190-30-2, Name is 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one, molecular formula is C24H29N7O2, molecular weight is 447.5328, MDL number is MFCD11840850, category is indole-building-block. Now introduce a scientific discovery about this category, Quality Control of 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one.
Trinuclear iron cluster and layered manganese complexes based on indolecarboxylic acid showing magnetic and antibacterial properties
Two novel iron and manganese complexes formulated as {[Fe-3(mu(3)-O)(H2O)(3)(I2CAH)(6)]center dot 2CH(3)OH center dot H2OCl}(n) (1) and {Mn(I2CAH)(2)(H2O)}(n) (2), (I2CAH(2) = Indole-2-carboxylic acid), have been synthesized by conventional solution method and structurally characterized. Compound 1 presents a triangular cluster structure consisting of trinuclear iron ions bridged by a mu(3)-O and chelated with six I2CAH(-) ligands. Compound 2 exhibits a two dimensional (2D) layered structure, which is formed by the I2CAH(-) ligand linked with manganese ions through a mono dentate bridging mode. Magnetic studies reveal the existence of antiferromagnetic interactions in compounds 1 and 2. The antibacterial activities of compounds 1 and 2 against Escherichia coli and Staphylococcus aureus have been investigated. The results show that the antibacterial activity of compound 1 is significantly better than that of compound 2.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles