Recently I am researching about PROTEIN TRANSLOCATION; BIOLOGICAL EVALUATION; APRATOXIN; PACLITAXEL; INHIBITOR; BLOCKADE; SQUAMOSA; INSIGHTS; REVEALS; LEAVES, Saw an article supported by the National Institute of General Medical Sciences of the National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [2R15GM116032-02A1]; Ball State University (BSU) Provost Startup Award; Wellcome Trust Investigator Award in Science [204957/Z/16/Z]; BSU. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zong, GH; Hu, ZJ; Duah, KB; Andrews, LE; Zhou, JH; O’Keefe, S; Whisenhunt, L; Shim, JS; Du, YC; High, S; Shi, WQ. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid. Computed Properties of C5H8O2
Two new ring-size-varying analogues (2 and 3) of ipomoeassin F were synthesized and evaluated. Improved cytotoxicity (IC50: from 1.8 nM) and in vitro protein translocation inhibition (IC50: 35 nM) derived from ring expansion imply that the binding pocket of Sec61 alpha (isoform 1) can accommodate further structural modifications, likely in the fatty acid portion. Streamlined preparation of the key diol intermediate 5 enabled gram-scale production, allowing us to establish that ipomoeassin F is biologically active in vivo (MTD: similar to 3 mg/kg).
Computed Properties of C5H8O2. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Zong, GH; Hu, ZJ; Duah, KB; Andrews, LE; Zhou, JH; O’Keefe, S; Whisenhunt, L; Shim, JS; Du, YC; High, S; Shi, WQ or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles