Taha, I; Keshk, EM; Khalil, AGM; Fekri, A in [Taha, Israa; Keshk, Eman M.; Khalil, Abdel-Galil M.; Fekri, Ahmed] Mansoura Univ, Fac Sci, Chem Dept, 25 El Gomhouria St, Mansoura 35516, Dakahlia Govern, Egypt published Synthesis, characterization, antibacterial evaluation, 2D-QSAR modeling and molecular docking studies for benzocaine derivatives in 2021, Cited 47. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
Possible application of incorporating a well-known drug (benzocaine) with cyanoacetamide function to get a powerful synthon ethyl 4-cyanoacetamido benzoate. This synthetic intermediate was used as a precursor for the synthesis of triazine, pyridone, thiazolidinone, thiazole and thiophene scaffolds containing the benzocaine core. Facile coupling, Michael addition, condensation and nucleophilic attack reactions were used to synthesize our targets. The structural features of the synthesized scaffolds were characterized using IR,H-1 NMR,C-13 NMR and mass spectroscopy. The antibacterial activities against Gram-positive (Staphylococcus aureus,Bacillus subtilis) and Gram-negative bacteria (Escherichia coli,Pseudomonas aeruginosa) were evaluated using ampicillin as a reference drug. DNA/methyl-green colorimetric assay of the DNA-binding compounds was also performed. Theoretical studies of the newly synthesized compounds based on molecular docking and QSAR study were conducted. The molecular docking studies were screened by MOE software for the more potent antibacterial agent28band each native ligand against four ofS. aureusproteins 1jij, 2xct, 2w9s and 3t07. [GRAPHICS] .
Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Taha, I; Keshk, EM; Khalil, AGM; Fekri, A or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles