Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 521984-48-5, Name is SIS3, molecular formula is , belongs to indole-building-block compound. In a document, author is Borpatra, Paran J., Safety of SIS3.
Here, we have developed a 3-component one-pot sequential approach to 3-substituted indoles. The main advantages of this process are step economy, reduced waste, and operational simplicity. The method involves in situ generation of 3-indolylalcohols from the reaction of indoles and aldehydes in the presence of base. Further, nucleophilic substitution of 3-indolylalcohols with various nucleophiles affords 3-substituted indole derivatives. The reaction does not requires any hazardous and expensive metal catalyst. In addition, the reaction is carried out in (1:1) ethanol-water which is considered as environmentally benign solvent. On the other hand, nonsequential 3-component reaction results in the formation of unwanted bisindolylmethanes. [GRAPHICS] .
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles