Let’s face it, organic chemistry can seem difficult to learn, Recommanded Product: 10580-19-5, Especially from a beginner’s point of view. Like 10580-19-5, Name is Sodium 4-hydroxybenzenesulfonate dihydrate, molecular formula is indole-building-block, belongs to indole-building-block compound. In a document, author is Zhao, Yun-Hui, introducing its new discovery.
Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramolecular cyclization, nucleophilic addition of indole, and subsequent N-N bond cleavage. The transformation from readily available starting materials into an interesting class of indole-substituted isoquinolines was completed under mild conditions and by simple operations in moderate to good yields. The antitumor activity of these compounds in vitro was significantly greater than that of a reference compound, 5-fluorouracil. The products might serve as new lead compounds for drugs for the treatment of cancer.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles