Electric Literature of 2022-85-7, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2022-85-7, Name is 5-Fluorocytosine, SMILES is O=C1NC(=C(F)C=N1)N, belongs to indole-building-block compound. In a article, author is Xie, Hui, introduce new discover of the category.
A Cascade Rh(III)-catalyzed C-H Activation/Chemodivergent Annulation of N-carbamoylindoles with Sulfoxonium Ylides for the Synthesis of Dihydropyrimidoindolone and Tricyclic [1,3]Oxazino[3,4-a]indol-1-ones Derivatives
A highly efficient cascade Rh(III)-catalyzed C-H activation/intramolecular chemodivergent cyclization reaction of N-carbamoylindoles and sulfoxonium ylides has been successfully achieved for the first time. This synergistic process provides rapid access to functionalized dihydropyrimidoindolone and tricyclic [1,3]oxazino[3,4-a]indol-1-ones skeletons under redox neutral conditions with broad substrate scope and remarkable functional-group compatibility. Further late-stage modification of structurally complex drug molecules and mechanistic studies were also accomplished.
Electric Literature of 2022-85-7, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2022-85-7 is helpful to your research.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles