An article Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis WOS:000461537000012 published article about FLUCONAZOLE; COMBINATION in [Tu, Jie; Li, Zhuang; Jiang, Yanjuan; Ji, Changjin; Han, Guiyan; Wang, Yan; Liu, Na; Sheng, Chunquan] Second Mil Med Univ, Sch Pharm, Dept Med Chem, 325 Guohe Rd, Shanghai 200433, Peoples R China in 2019.0, Cited 40.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Formula: C7H8O2
Clinical treatment of cryptococcal meningitis (CM) remains a significant challenge because of the lack of effective and safe drug therapies. Developing novel CM therapeutic agents with novel chemical scaffolds and new modes of action is of great importance. Herein, new beta-hexahydrocarboline derivatives are shown to possess potent anticryptococcal activities. In particular, compound A4 showed potent in vitro and in vivo anticryptococcal activity with good metabolic stability and blood-brain barrier permeability. Compound A4 was orally active and could significantly reduce brain fungal burdens in a murine model of CM. Moreover, compound A4 could inhibit several virulence factors of Cryptococcus neoformans and might act by a new mode of action. Preliminary mechanistic studies revealed that compound A4 induced DNA double-stranded breaks and cell cycle arrest at the G2 phase by acting on the Cdc25c/CDK1/cyclin B pathway. Taken together, beta-hexahydrocarboline A4 represents a promising lead compound for the development of next-generation CM therapeutic agents.
About m-Methoxyphenol, If you have any questions, you can contact Tu, J; Li, Z; Jiang, YJ; Ji, CJ; Han, GY; Wang, Y; Liu, N; Sheng, CQ or concate me.. Formula: C7H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles