SDS of cas: 100-51-6. In 2019.0 BIOORGAN MED CHEM published article about PHENOLIC-COMPOUNDS; PHASE ADVANCES; ANTAGONISTS; DERIVATIVES; ACTIVATION; MT1 in [Chen, Si-Yue; Geng, Chang-An; Ma, Yun-Bao; Huang, Xiao-Yan; Yang, Xiao-Tong; Su, Li-Hua; He, Xiao-Feng; Li, Tian-Ze; Deng, Zhen-Tao; Gao, Zhen; Zhang, Xue-Mei; Chen, Ji-Jun] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; [Chen, Si-Yue; Geng, Chang-An; Ma, Yun-Bao; Huang, Xiao-Yan; Yang, Xiao-Tong; Su, Li-Hua; He, Xiao-Feng; Li, Tian-Ze; Deng, Zhen-Tao; Gao, Zhen; Zhang, Xue-Mei; Chen, Ji-Jun] Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China; [Chen, Si-Yue; Yang, Xiao-Tong; Su, Li-Hua; He, Xiao-Feng; Deng, Zhen-Tao; Gao, Zhen; Chen, Ji-Jun] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2019.0, Cited 29.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, nine polybenzyls (1-9), including six new ones (2-5, 7 and 9), were isolated from the EtOAc extract of G. elata. Five compounds 1, 3, 4, 6 and 8 were found to activate melatonin receptors. Especially, compound 1 showed agonistic effects on MT1 and MT2 receptors with EC50 values of 237 and 244 mu M. For better understanding their structure-activity relationships (SARs), ten polybenzyl analogs were further synthesized and assayed for their activities on melatonin receptors. Preliminary SARs study suggested that two para-hydroxy groups were the key pharmacophore for maintaining activity. Molecular docking simulations verified that compound 1 could strongly interact with MT2 receptor by bonding to Phe 118, Gly 121, His 208, Try 294 and Ala 297 residues.
Welcome to talk about 100-51-6, If you have any questions, you can contact Chen, SY; Geng, CA; Ma, YB; Huang, XY; Yang, XT; Su, LH; He, XF; Li, TZ; Deng, ZT; Gao, Z; Zhang, XM; Chen, JJ or send Email.. SDS of cas: 100-51-6
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles