Category: indole-building-block. Recently I am researching about ORGANIC FLUOROPHORES; DYE; OSTEOSARCOMA; FLUORESCENCE; MECHANISMS; RELEASE; DESIGN; BRIGHT; PROBES, Saw an article supported by the National Key R&D Program of China [2020YFA0908800]; NSFCNational Natural Science Foundation of China (NSFC) [81773674, 81573383]; Shenzhen Science and Technology Research Grant [JCYJ20190808152019182]; National Natural Science Foundation of Hubei Province [2017CFA024, 2017CFB711]; Applied Basic Research Program of Wuhan Municipal Bureau of Science and Technology [2019020701011429]; Tibet Autonomous Region Science and Technology Plan Project Key Project [XZ201901-GB-11]; Local Development Funds of Science and Technology Department of Tibet [XZ202001YD0028C]; Chengdu University of Traditional Chinese Medicine [CZYJC1903]; Health Commission of Hubei Province Scientific Research Project [WJ2019M177, WJ2019M178]; China Scholarship CouncilChina Scholarship Council; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Hubei Province Scientific and Technical Innovation Key Project. Published in NATURE RESEARCH in BERLIN ,Authors: Zhou, H; Zeng, XD; Li, AG; Zhou, WY; Tang, L; Hu, WB; Fan, QL; Meng, XL; Deng, H; Duan, L; Li, YQ; Deng, ZX; Hong, XC; Xiao, YL. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at similar to 580nm upon excitation at similar to 850nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency. Currently available mitochondria-targeted fluorescent dyes emit only one color in the visible or NIR-I and their applications are limited. Here, the authors develop upconversion mitochondria-targeted NIR-II fluorophores for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and photothermal efficiency
Category: indole-building-block. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhou, H; Zeng, XD; Li, AG; Zhou, WY; Tang, L; Hu, WB; Fan, QL; Meng, XL; Deng, H; Duan, L; Li, YQ; Deng, ZX; Hong, XC; Xiao, YL or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles