The author of 《Palladium-catalyzed regioselective C-H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles》 were Fang, Songjia; Jiang, Guangbin; Li, Meng; Liu, Zhenying; Jiang, Huanfeng; Wu, Wanqing. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Safety of 5-Fluoro-1H-indole The author mentioned the following in the article:
A Pd-catalyzed uniquely regioselective C-H alkynylation of indoles was described. In this protocol, simple and readily available haloalkynes are employed as efficient alkynylating reagents, affording functionalized 7-alkynylindoles in moderate to good yields. Also, further transformations of 7-alkynylated products were performed, which demonstrated the potential application of this method in organic synthesis. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Safety of 5-Fluoro-1H-indole)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Safety of 5-Fluoro-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles