Enantioseparation of derivatives of amino acids on silica modified by macrocyclic antibiotic eremomycin was written by Fedorova, I. A.;Shapovalova, E. N.;Staroverov, S. M.;Shpigun, O. A.. And the article was included in Sorbtsionnye i Khromatograficheskie Protsessy in 2015.HPLC of Formula: 7432-21-5 This article mentions the following:
Macrocyclic antibiotic eremomycin is using as chiral selector in chiral HPLC. Sorbents with this antibiotic permit to enantiosep. optical isomers of amino acids and their derivatives The main purpose of this paper was the investigation of enantioseparation of benzyloxycarbonyl (Cbz), tert-butyloxycarbonyl (Boc) derivatives of amino acids on sorbent with eremomycin. Retention time and efficiency of enantioseparation depend on structure of amino acid and radical of derivatives Retentions time of derivatives of amino acids on eremomycin increase in the row Boc < benzoyl < Cbz. More complicated structure, the presence of aromatic rings improve the enantioseparation Comparison of the results on vancomycin-sorbent shows the most successful enantioseparation on the eremomycin. In the experiment, the researchers used many compounds, for example, (S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid (cas: 7432-21-5HPLC of Formula: 7432-21-5).
(S)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid (cas: 7432-21-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 7432-21-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles