Chemistry is an experimental science, SDS of cas: 1912-48-7, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1912-48-7, Name is 1-Methyl-3-indoleacetic acid
“Chemical equation presented” A concise asymmetric total synthesis of (-)-vindoline (1) is detailed based on a tandem intramolecular [4+2]/[3+2] cycloaddition cascade of a 1,3,4-oxadiazole inspired by the natural product structure, in which the tether linking the initiating dienophile and oxadiazole bears a chiral substituent that controls the facial selectivity of the initiating Diels-Alder reaction and sets absolute stereochemistry of the remaining six stereocenters in the cascade cycloadduct. This key reaction introduces three rings and four C-C bonds central to the pentacyclic ring system setting all six stereocenters and introducing essentially all the functionality found in the natural product in a single step. Implementation of the approach also required the development of a unique ring expansion reaction to provide a six-membered ring suitably functionalized for introduction of the .(6, 7)-double bond found in the core structure of vindoline and defined our use of a protected hydroxymetyl group as the substituent used to control the stereochemical course of the cycloaddition cascade.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 1912-48-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1912-48-7, in my other articles.
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles