In 2019.0 MED CHEM published article about RADICAL SCAVENGING ABILITY; ANTIOXIDANTS in [Bettencourt, Ana P.; Fernandes, Francisco; Proenca, Maria Fernanda; Areias, Filipe M.] Univ Minho, Dept Chem, Campus Gualtar, P-4710057 Braga, Portugal; [Castro, Marian] Univ Santiago de Compostela, BioFarma Res Grp, Ctr Res Mol Med & Chron Dis CiMUS, Ave Barcelona 22, Santiago De Compostela 15782, Spain; [Silva, Joao P.; Coutinho, Olga P.] Univ Minho, Dept Biol, Campus Gualtar, P-4710057 Braga, Portugal; [Sousa, Maria J.; Areias, Filipe M.] Univ Minho, CBMA Ctr Mol & Environm Biol, Dept Biol, Campus Gualtar, P-4710057 Braga, Portugal; [Areias, Filipe M.] Yachay Tech Univ, Sch Chem Sci & Engn, Yachay City Of Knowledge 100650, Urcuqui, Ecuador in 2019.0, Cited 33.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 3-Hydroxybenzaldehyde
Background: Previous publications show that the addition of a phenolic antioxidant to an antifungal agent, considerably enhances the antifungal activity. Objective: Synthesis of novel compounds combining phenolic units with linear or cyclic nitrogencontaining organic molecules with antioxidant/antifungal activity using methodologies previously developed in the group. Methods: Several N- [1,2-dicyano-2- (arylidenamino) vinyl]-O-alkylformamidoximes 3 were synthesized and cyclized to 4,5-dicyano-N- (N’-alcoxyformimidoyl)-2-arylimidazoles 4 upon reflux in DMF, in the presence of manganese dioxide or to 6-cyano-8-arylpurines 5 when the reagent was refluxed in acetonitrile with an excess of triethylamine. These compounds were tested for their antioxidant activity by cyclic voltammetry, DPPH radical (DPPH.) assay and deoxyribose degradation assay. The minimum inhibitory concentration (MIC) of all compounds was evaluated against two yeast species, Saccharomyces cerevisiae and Candida albicans, and against bacteria Bacillus suhtill’s (Gram-positive) and Escherichia call (Gram negative). Their cytotoxicity was evaluated in fibroblasts. Results: Among the synthetised compounds, five presented higher antioxidant activity than reference antioxidant Trolox and from these compounds, four presented antifungal activity without toxic effects in fibroblasts and bacteria. Conclusion: Four novel compounds presented dual antioxidant/antifimgal activity at concentrations that are not toxic to bacteria and fibroblasts. The active molecules can be used as an inspiration for further studies in this area.
Welcome to talk about 100-83-4, If you have any questions, you can contact Bettencourt, AP; Castro, M; Silva, JP; Fernandes, F; Coutinho, OP; Sousa, MJ; Proenca, MF; Areias, FM or send Email.. Recommanded Product: 3-Hydroxybenzaldehyde
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles