In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 184151-49-3, name is Methyl 3-methyl-1H-indole-6-carboxylate, introducing its new discovery. Formula: C11H11NO2
The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; compounds that are part of a subclass of these substituted pyrrolidine compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; new compounds that are part of a subclass of these substituted pyrrolidine compounds; pharmaceutical formulations comprising said substituted pyrrolidine compounds, and/or a method of treatment comprising administering said substituted pyrrolidine compounds, a method for the manufacture especially of said new substituted pyrrolidine compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The substituted pyrrolidine compounds are of the formula (I), wherein R1, R2, R3, R4, R5 and T are defined as in the specification.Lambda”invention concerne l”utilisation de composes pyrrolidine (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substitues dans la preparation d”une formulation pharmaceutique destinee au traitement d”une maladie dependant de l”activite de la renine; l”utilisation d”un compose de cette classe dans le traitement d”une maladie dependant de l”activite de la renine; des composes qui font partie d”une sous-classe desdits composes pyrrolidine substitues et qui sont destines au diagnostic et au traitement therapeutique d”un animal a sang chaud, en particulier au traitement d”une maladie (d”un trouble) dependant de l”activite de la renine; de nouveaux composes qui font partie d”une sous-classe desdits composes pyrrolidine substitues; des formulations pharmaceutiques comprenant lesdits composes pyrrolidine, et/ou un procede de traitement qui consiste a administrer lesdits composes pyrrolidine substitues, un procede de fabrication en particulier desdits nouveaux composes pyrrolidine substitues, ainsi que de nouveaux intermediaires, des matieres premieres et/ou des etapes partielles de leur synthese.Les composes pyrrolidine substitues de l”invention repondent a la formule (I) suivante, dans laquelle R1, R2, R3, R4, R5 et T sont tels que definis dans la description.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 184151-49-3 is helpful to your research. name: Methyl 3-methyl-1H-indole-6-carboxylate
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles