19012-03-4. Name is 1-Methyl-1H-indole-3-carbaldehyde, belongs to indole-building-block compound, is a common compound. In an article, authors is Bakkolla, Mahesh Goud, once mentioned the new application about 19012-03-4.
A simple and facile synthesis of novel 1,2,3-triazole substituted pyrimidine derivatives
A series of novel indole and pyrimidine scaffolds bearing 1,2,3-triazoles have been designed and synthesized using click chemistry reaction conditions. Target compounds 9a-j were synthesized in the multi-step process. In the first step 5-substituted-1-methyl-1H-indole-3-carbaldehyde 2a-b reacted with ethyl cyanoacetate 3 and guanidine hydrochloride 4 in presence of L-Proline in ethanol undergoes cyclisation to form 5a-b. Further, 5a-b condensed with various benzaldehydes to form Schiff’s base 6a-f, which further proporgylated with propargyl bromide to form 7a-f. Finally, 7a-f was subjected to click-chemistry with various azides in the presence of CuSO4.5H2O + sodium ascorbate mixture in Dimethylformamide at room temperature to obtain 2 + 3 cycloaddition products 9a-j in high yield. All these synthetic methods are mostly green and inexpensive with excellent yields.
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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles