Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 371935-74-9, Name is PI-103, molecular formula is C19H16N4O3. In an article, author is Kim, Hyung Joo,once mentioned of 371935-74-9, Category: indole-building-block.
Herein, we describe the development of a two-step protocol for the synthesis of 2-substituted tryptamine derivatives from 2-aminocinnamyl nitriles and aldehydes. The cyanide-catalyzed imino-Stetter reaction of 2-aminocinnamyl nitriles and aldehydes provided 2-substituted indole-3-acetonitrile derivatives. Subsequent reduction of the nitrile group afforded the desired 2-substituted tryptamine derivatives. The utility of this protocol was demonstrated in the synthesis of a potential inhibitor of 15-lipoxygenase. Furthermore, the resulting 2-substituted indole-3-acetonitriles were converted to several 2,3-disubstituted indole derivatives upon transformation of the nitrile group into other functional groups.
If you’re interested in learning more about 371935-74-9. The above is the message from the blog manager. Category: indole-building-block.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles