In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 827-01-0, name is 5-Chloroindole-3-carboxaldehyde, introducing its new discovery. HPLC of Formula: C9H6ClNO
We previously reported the discovery of a simple conjugated cyano pharmacophore which had led to the development of (Z)-2-(3,4-dichlorophenyl)-3- (4-nitrophenyl)acrylonitrile (1), as a selective inhibitor of oestrogen receptor positive (ER+ve) human breast cancer cell line, MCF-7. Further exploration though modification of the acrylonitrile and aromatic substituents has highlighted key structural components necessary for broad spectrum cytotoxicity. The acrylic acid derivates (Z)-2-(3,4-dichlorophenyl)-3-(4-nitrophenyl)acrylic acid (8) and (Z)-2-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)acrylic acid (9) were inactive; confirming the importance of the cyanide moiety. The most potent 2-phenylacrylonitriles synthesized were (Z)-2-(3,4-dichlorophenyl)-3-(1H-indol- 3-yl)acrylonitrile (3) and (Z)-2-(3,4-dichlorophenyl)-3-(1H-indol-5-yl) acrylonitrile (20) with an average GI50 values of 1.4 and 0.53 muM respectively. Five additional (Z)-2-(3,4-dichlorophenyl)-3-(indolyl) acrylonitriles also displayed average GI50 values of ?8.4 muM. In the case of indole 20, this represents a 32-fold increase in broad spectrum cytotoxicity relative to the lead (1).
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 827-01-0 is helpful to your research. COA of Formula: C9H6ClNO
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles