The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 157115-85-0, Name is Noopept, SMILES is O=C(OCC)CNC([C@H]1N(C(CC2=CC=CC=C2)=O)CCC1)=O, in an article , author is He, Yang, once mentioned of 157115-85-0, Application In Synthesis of Noopept.
A PRACTICAL SYNTHESIS OF 2-SUBSTITUTED 5-BROMOINDOLES
This paper describes a non-cryogenic synthetic procedure for a variety of 2-substituted 5-bromoindoles. The direct magnesiation of 5-bromo-1-(4-toluenesulfonyl)indole with a mixture of i-PrMgCl/LiCl and diisopropylamine allows for the preparation of various 2-substituted indoles. The advantages of this procedure include the non-cryogenic conditions, simple operations and inexpensive Grignard reagents. In addition, this procedure is especially advantageous for the preparation of 2,5-dibromoindole with reduced synthetic steps, low production cost and good overall yields.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles