SDS of cas: 123-11-5. Authors Saigal; Ghanem, YSA; Uddin, A; Khan, S; Abid, M; Khan, MM in WILEY-V C H VERLAG GMBH published article about in [Khan, Sarfaraz; Khan, Md. Musawwer] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India; [Uddin, Amad; Abid, Mohammad] Jamia Millia Islamia, Med Chem Lab, Dept Biosci, New Delhi 110025, India in 2021.0, Cited 65.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
The synthesis and antibacterial studies of polysubstituted pyrrolo[3,4-b]pyridine derivatives have been described. The preparation of pyrrolo[3,4-b]pyridine derivatives was carried out by the reaction of enamino imides, aromatic aldehydes and malononitrile/ethyl cyanoacetate using 10 mol % of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) in ethanol at 78 degrees C in good yields. The compounds were characterized by standard spectroscopic techniques including IR, H-1 & C-13 NMR and elemental analysis and also final confirmation was done by single crystal X-ray. The antibacterial activity of all the synthesized compounds was tested against two Gram positive (S. pneumoniae MTCC 655 and E. faecalis MTCC 439) and three Gram negative (E. coli ATCC 25922, S. typhimurium MTCC 3224, and P. aeruginosa MTCC 2453) bacterial strains. Most of the tested compounds showed moderate to good antibacterial activity. Compounds pyrrolo[3,4-b]pyridine derivatives (4 j and 4 l) were the most potent and displayed bactericidal activities against E. coli strain with MIC (minimum inhibitory concentration) values of 62.5 mu g/mL and 125.0 mu g/mL respectively. Growth kinetic studies against E. coli, toxicity studies using human RBCs (red blood cells) and also docking studies of the selected compounds 4 j and 4 l supported that these compounds inhibit the growth of bacterial cells, non-toxic in nature and interact with key amino residues of DNA (deoxyribonucleic acid) duplex (PDBID: 1BNA) and have drug-like properties.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles