Synthetic Route of 15861-24-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 15861-24-2, Name is Indole-5-carbonitrile, molecular formula is C9H6N2. In a Article£¬once mentioned of 15861-24-2
Organocatalytic synthesis of alpha-quaternary amino acid derivatives via aza-Friedel-Crafts alkylation of indoles with simple alpha-amidoacrylates
The first (organo)catalytic method for regio- and chemoselective aza-Friedel-Crafts (FC) alkylation of indoles and pyrroles with commercially available methyl alpha-acetamidoacrylates has been discovered. It minimizes/eliminates common competing reactions that occur due to the high and multiatom-nucleophilic character of indole and pyrrole. Diverse quaternary alpha-amino acids were successfully prepared in good yield and high selectivity using low catalyst loading. The enantioselective variant using BINOL-derived phosphoric acids was also explored with indole providing the desired F-C alkylation product with moderate enantioselectivities.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 15861-24-2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 15861-24-2, in my other articles.
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Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles