Category: indole-building-block. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors. Author is Wei, Huiqiang; Guo, Jianghong; Sun, Xiao; Gou, Wenfeng; Ning, Hongxin; Fang, Zhennan; Liu, Qiang; Hou, Wenbin; Li, Yiliang.
SUMOylation and deSUMOylation plays an important role in DNA damage response and the formation of radiotherapy resistance. SENP1 is the main specific isopeptidase to catalyze deSUMOylation modification. Inhibiting SENP1 upregulates cancer cell radiosensitivity and it becomes a promising target for radiosensitization. Herein, based on the structure of ursolic acid (UA), a total of 53 pentacyclic triterpene derivatives were designed and synthesized as SENP1 inhibitors. Ten derivatives exhibited better SENP1 inhibitory activities than UA and the preliminary structure-activity relationship was discussed. Most of the UA derivatives were low-cytotoxic, among which compound 36 showed the best radiosensitizing activity with the SER value of 1.45. It was the first study to develop small mol. SENP1 inhibitors as radiosensitizers.
In addition to the literature in the link below, there is a lot of literature about this compound(1,4-Dibromobutane)Category: indole-building-block, illustrating the importance and wide applicability of this compound(110-52-1).
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles