Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression was written by Frycia, Anne;Starck, Jean-Philippe;Jadot, Sophie;Lallemand, Benedicte;Leclercq, Karine;Lo Brutto, Patrick;Matagne, Alain;Verbois, Valerie;Mercier, Joel;Kenda, Benoit. And the article was included in ChemMedChem in 2010.Synthetic Route of C11H11NO2 This article mentions the following:
Capitalizing on the proven clin. efficacy of levetiracetam (I) as an antiepileptic drug, a drug discovery program led to the identification of a new generation of SV2A ligands with equal or better tolerability profiles than levetiracetam, and improved potency toward seizure suppression in animal models. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0Synthetic Route of C11H11NO2).
5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Synthetic Route of C11H11NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles